https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45150 Wed 26 Oct 2022 19:29:23 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4329 Wed 11 Apr 2018 16:27:34 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45583 Wed 02 Nov 2022 10:33:57 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45367 Thu 27 Oct 2022 15:37:47 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9648 60 years is growing faster than any other age group and is expected to reach 2 billion worldwide by 2050. Internationally and nationally, considerable efforts are being made to promote active ageing. However, Australia lacks the kind of comprehensive longitudinal research underway in Europe and North America. Although Australia does have a number of longitudinal studies designed to address various issues of health and ageing among older adults, only a few of these studies include a broad and comprehensive range of physical and biological measures. The Hunter Community Study (HCS) is a collaborative study between the University of Newcastle’s School of Medicine and Public Health and the Hunter New England Area Health Service. It is a multi disciplinary initiative that was established to fill some existing gaps in ageing research in Australia and is unique in that it has collected detailed information across all six key policy themes as identified in the Framework for an Australian Ageing Research Agenda.]]> Sat 24 Mar 2018 08:35:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14791 Sat 24 Mar 2018 08:26:27 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19672 Sat 24 Mar 2018 08:01:12 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21170 ®, MEDLINE^®, EMBASE, SPORTDiscus™, Scopus, Web of Science, and Informit; using the key search terms: diffusion tensor imaging, diffusion magnetic resonance imaging, diffusion weighted MRI, diffusion MRI, fractional anisotropy, tractography, apparent diffusion coefficient, magnetic resonance imaging, mild traumatic brain injury, mTBI, traumatic brain injury, concussion, sport, athletic and athlete. Observational, cohort, correlation, cross-sectional and longitudinal studies were all included in the current review. Results of the review found eight articles that met inclusion criteria, which included data on 214 athletes and 96 controls. Seven of eight studies reported some type of DTI abnormality, although the neuroanatomical sites involved varied. Although considerable methodological variations exist across studies, the current review suggests that DTI may possess adequate diagnostic sensitivity to detect SRC in affected athletes. Further longitudinal studies are required to demonstrate its discriminate validity and prognostic capacity within this field.]]> Sat 24 Mar 2018 07:58:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17876 Sat 24 Mar 2018 07:56:43 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21648 Sat 24 Mar 2018 07:52:23 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19394 Sat 24 Mar 2018 07:52:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27385 -6) was sought in 10,617 participants of European descent, 3811 African-Americans, and 1561 young adults. Results: rs4420638, near APOE, was associated with poorer delayed recall performance in discovery (p = 5.57 x 10^-10) and replication cohorts (p = 5.65 x 10^-8). This association was stronger for paragraph than word list delayed recall and in the oldest persons. Two associations with specific tests, in subsets of the total sample, reached genome-wide significance in combined analyses of discovery and replication (rs11074779 [HS3ST4], p = 3.11 x 10^-8, and rs6813517 [SPOCK3], p = 2.58 x 10^-8) near genes involved in immune response. A genetic score combining 58 independent suggestive memory risk variants was associated with increasing Alzheimer disease pathology in 725 autopsy samples. Association of memory risk loci with gene expression in 138 human hippocampus samples showed cis-associations with WDR48 and CLDN5, both related to ubiquitin metabolism. Conclusions: This largest study to date exploring the genetics of memory function in ~40,000 older individuals revealed genome-wide associations and suggested an involvement of immune and ubiquitin pathways.]]> Sat 24 Mar 2018 07:34:11 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28452 Sat 24 Mar 2018 07:29:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26680 Sat 24 Mar 2018 07:26:17 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38394 Mon 29 Jan 2024 17:47:23 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8539 Mon 23 Sep 2019 11:55:24 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51778 Mon 18 Sep 2023 15:11:23 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54189 Mon 12 Feb 2024 14:08:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36215 Fri 06 Mar 2020 12:36:42 AEDT ]]>